By Sarah Constantin
We’re excited to announce the funding of our second lifespan study, a collaboration with Dr. Laura Dugan, the chair of the Division of Geriatric Medicine at Vanderbilt University Medical School, to pursue her research on C3 carboxyfullerenes.
Dr. Dugan has previously researched the neuroprotective, antioxidant, anti-inflammatory, and lifespan-extending effects of these molecules, whose unusual “buckyball” structure makes them catalytic superoxide dismutase mimetics, nearly 10,000 times more potent than classic antioxidants such as vitamin E or vitamin C.
LRI will fund Dr. Dugan and her collaborators at Vanderbilt to launch a dose-response lifespan study to test if higher doses of C3 will cause more lifespan extension than the 11% previously observed. Autopsies to observe diseases of aging, tests of motor and cognitive performance, and assessments of overall health will aslo be performed on the mice, as well as measurements of markers of inflammation in heart, kidney, muscle, and brain tissues.
Congratulations to Dr. Dugan for receiving our first academic grant, and we look forward to seeing the results of her research!
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